Utility of pVHL, Maspin, S100P and IMP3 in Diagnosis of Carcinomas from Various Organs.
Fan Lin, Hanlin L Wang, Myra Wilkerson, Haiyan Liu. Geisinger Medical Center, Danville, PA; Cedars-Sinai Medical Center, Los Angeles, CA
Background: Our studies demonstrated that pVHL, S100P, maspin, and IMP3 were the useful panel of antibodies in confirming a diagnosis of pancreatobiliary adenocarcinoma (AJSP 2008;32:78; Hum Pathol 2010;40:324), and pVHL was a sensitive and specific marker for identifying clear cell carcinoma of the kidney, uterus and ovary (AJCP 2008;129:592). In this study, we investigate the potential utility of these markers in the diagnosis of carcinomas from other organs.
Design: Immunohistochemical evaluation of the expression of pVHL, maspin, S100P and IMP3 was performed on a total of 900 cases of carcinomas from various organs on tissue microarray sections.
Results: The positive immunostaining results (%) and a total number of cases for each entity (N) are summarized in the Table 1. Twenty-two cases of intratubular germ cell neoplasia (ITGCN) were all positive for IMP3.
|Tumor||pVHL (%)||Maspin (%)||S100P (%)||IMP3 (%)|
|Lung ADC (N=54)||4||51||4||65|
|Colonic ADC (N=38)||16||90||55||50|
|Thyroid papillary CA (N=45)||0||9||0||4|
|Thyroid follicular CA (N=36)||0||8||0||0|
|Esophageal ADC (N=30)||13||100||73||57|
|Gastric ADC (N=18)||0||67||67||56|
|Pancreatic ADC (N=70)||0||100||96||90|
|Gallbladder ADC (N=23)||0||100||74||78|
|Urothelial CA (N=40)||0||65||68||35|
|Intrahepatic cholangiocarcinoma (ICC) (N=11)||73||27||9||55|
|Breast ductal CA (N=176)||0||26||24||6|
|Lobular CA (N=83)||4||31||55||6|
|Endocervical ADC (N=17)||6||65||47||53|
|Ovarian serous CA (N=15)||0||27||0||53|
|Prostatic ADC (N=100)||0||2||1||0|
|Embryonal CA (N=24)||0||21||0||100|
|Yolk sac tumor (N=12)||0||17||0||100|