Spectrum of Liver Pathology and Laboratory Findings in HIV Patients with and without Hepatitis C Coinfection.
Jeffrey A Eisenstein, Matthew G Lim, Matthew M Coates, Marina B Mosunjac. Emory University, Atlanta, GA
Background: Liver abnormalities are common in HIV patients. The reported prevalence and the impact of HIV/HCV coinfection vary significantly among studies. The aim of this study was to evaluate histological, clinical and laboratory findings in HIV patients of an inner-city hospital,with and without Hepatitis C (HCV) coinfection
Design: Clinical and pathologic data was obtained on 168 HIV-positive patients with liver biopsies (LB) from the years 2005-2010 at Grady Memorial Hospital. A retrospective search of medical records categorized patients by age, sex, biopsy indication, pathologic diagnosis and hepatitis serologies.
Results: Patients age ranged from 22-69 (mean 46.5) years with a 2.4:1 male to female ratio. 137 patients were co-infected with HCV. Of the 137 patients, 44 were additionally coinfected with Hepatitis B (HBV). We identified 31 HCV seronegative patients, 8 whom were co-infected with HBV. The remaining 23 patients had HIV only and had LBs for various clinical and laboratory indications including elevated liver enzymes.
|ALT [IU/L] range; mean; SD||ALT [IU/L] range; mean; SD||# Stage 3 and 4 (%)|
|Hep C+, Hep B- (N=93)||13-304; 70.7; 61.3||13-466; 71.5; 64.3||25 (26.9)|
|Hep C-, Hep B- (N=23)||11-203; 92.5; 66.8||17-613; 183.4; 187.1||4 (17.4)|
|Hep C+, Hep B+ (N=44)||20-398; 74.9; 70.3||21-888; 101.1; 138.1||15 (34.1)|
|Hep C-, Hep B+ (N=8)||23-507; 120.5; 160.1||29-914; 197.3; 296.4||4 (50)|