Prevalence of Herpes Simplex Virus Type-2 Seropositivity in Women with Atypical Recurrent Genital Symptoms.
Cary Chisholm, Arundhati Rao, Thomas Kuehl, Patricia Sulak. Scott & White Memorial Hospital, Temple, TX
Background: Herpes simplex virus type-2 is identified in 17% of people in the United States between the ages of 14-49. Women with atypical recurrent genital symptoms (itching, burning, skin fissures, erythema) represent a population which is frequently misdiagnosed or ignored. Since those with HSV-2 have a two to four times higher risk of acquiring and transmitting HIV, it is prudent to determine if HSV-2 is the etiology behind these abnormal symptoms.
Design: A retrospective review was performed of all HSV-2 and HSV-1 antibody assays ordered during a 12 month interval. Data regarding demographics, reasons for ordering, and antibody prevalence were extracted from medical records without patient identifiers and reported as percentages for various subgroups of women with 95% confidence intervals. Groups with and without genital symptoms were compared using Chi-square test.
Results: HSV-2 antibodies were detected in 30% of 290 women between 14 and 64 years of age undergoing screening without symptoms including patients with screening directed by a healthcare provider (29.6%) or requested by the patient (30%). The frequency of HSV-2 positive test results were significantly (p = 0.004) greater in those with the occurrence of atypical recurrent clinical symptoms (47% of 88 patients). Women with atypical recurrent genital symptoms and positive HSV-2 test results were more likely (p = 0.038, Chi-square test) to also be positive for HSV-1 (69% of 26) than those with negative HSV-2 test results (41% of 29).
Conclusions: The frequency of HSV-2 positivity in central Texas women screened for various reasons was greater than a general mixed gender population. The frequency of positivity was greater in women with atypical recurrent genital symptoms compared to those screened as part of routine patient care, and the prevalence was equal to those patients with a history of genital herpes. Women with recurrent genital symptoms are thus a high risk population which warrant screening and prophylactic treatment to prevent the spread of HSV-2.
Wednesday, March 2, 2011 1:00 PM
Poster Session VI # 230, Wednesday Afternoon