ITK and SYK Genes Involved Chromosome Translocation in Peripheral T-Cell Lymphomas.
Hongtao Ye, Wenyan Zhang, Baizhou Li, Gehong Dong, Yingqiong Zhou. Guilin Medical College, China; Hua Xi Hospital, Sichuan University, chengdu, China; Zhejiang University, Hangzhou, China; Tongren Hospital, Beijing, China
Background: Peripheral T-cell lymphomas (PTCLs) account for 10% of non-Hodgkin lymphomas. The genetic abnormality of PTCLs is poorly understood. t(5;9)(q33;q22)/ITK-SYK has been recently identified in a subgroup of PTCLs with follicular involvement. However, the frequency of t(5;9)(q33;q22)/ITK-SYK in PTCLs is unclear.
Design: Interphase fluorescence in situ hybridisation (FISH) to detect ITK and SYK genes involved chromosome translocations was used to investigate a series of 424 PTCLs. These included 168 cases of PTCL-U (PTCL, unspecified), 145 cases of NK/T-cell lymphoma (NKTL), 58 cases of anaplastic large-cell lymphoma (ALCL), 28 cases of angioimmunoblastic T-cell lymphoma (AITL) and 25 cases of enteropathy-associated T-cell lymphoma (EATL).
Results: In the 424 cases, we found only 1 case (0.2%) NKTL with ITK gene involved chromosome translocation. No SYK gene involved translocation was identified in all case. FISH analyses revealed that 14/168 (8%) PTCLs-U, 13/145 (9%) NKTLs, 5/58 (9%) ALCLs, 5/28 (18%) AITLs, 3/25 (12%) EATLs had 3 to 4 copies of ITK gene and 16/168 (10%) PTCLs, 10/145 (7%) NKTLs, 2/58 (4%) ALCLs, 4/25 (16%) EATLs had 3 to 4 copies of SYK gene.
Conclusions: The ITK and SYK genes involved chromosome translocations are rare in PTCLs. Three to four copies of ITK and SYK genes are common genetic abnormalities in PTCLs.
Wednesday, March 2, 2011 1:00 PM
Poster Session VI # 212, Wednesday Afternoon