[1404] ITK and SYK Genes Involved Chromosome Translocation in Peripheral T-Cell Lymphomas.

Hongtao Ye, Wenyan Zhang, Baizhou Li, Gehong Dong, Yingqiong Zhou. Guilin Medical College, China; Hua Xi Hospital, Sichuan University, chengdu, China; Zhejiang University, Hangzhou, China; Tongren Hospital, Beijing, China

Background: Peripheral T-cell lymphomas (PTCLs) account for 10% of non-Hodgkin lymphomas. The genetic abnormality of PTCLs is poorly understood. t(5;9)(q33;q22)/ITK-SYK has been recently identified in a subgroup of PTCLs with follicular involvement. However, the frequency of t(5;9)(q33;q22)/ITK-SYK in PTCLs is unclear.
Design: Interphase fluorescence in situ hybridisation (FISH) to detect ITK and SYK genes involved chromosome translocations was used to investigate a series of 424 PTCLs. These included 168 cases of PTCL-U (PTCL, unspecified), 145 cases of NK/T-cell lymphoma (NKTL), 58 cases of anaplastic large-cell lymphoma (ALCL), 28 cases of angioimmunoblastic T-cell lymphoma (AITL) and 25 cases of enteropathy-associated T-cell lymphoma (EATL).
Results: In the 424 cases, we found only 1 case (0.2%) NKTL with ITK gene involved chromosome translocation. No SYK gene involved translocation was identified in all case. FISH analyses revealed that 14/168 (8%) PTCLs-U, 13/145 (9%) NKTLs, 5/58 (9%) ALCLs, 5/28 (18%) AITLs, 3/25 (12%) EATLs had 3 to 4 copies of ITK gene and 16/168 (10%) PTCLs, 10/145 (7%) NKTLs, 2/58 (4%) ALCLs, 4/25 (16%) EATLs had 3 to 4 copies of SYK gene.
Conclusions: The ITK and SYK genes involved chromosome translocations are rare in PTCLs. Three to four copies of ITK and SYK genes are common genetic abnormalities in PTCLs.
Category: Hematopathology

Wednesday, March 2, 2011 1:00 PM

Poster Session VI # 212, Wednesday Afternoon


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