Extracavitary KSHV+ Large B-Cell Lymphoma: Time To Have a New Name?
Zenggang Pan, Zhengbin Lu, Lanting Liu, David B Wilson, Vishnu Reddy, Huanyou Wang, Yongsheng Ren. Univ. of Alabama at Birmingham; Ameripath, Indianapolis, IN; Univ. of California San Diego
Background: Extracavitary Kaposi sarcoma-associated herpesvirus (KSHV)+ large B-cell lymphoma (EK-LBL) has rarely been observed without effusions. It is uncertain whether it should be considered as a separated entity or a variant of primary effusion lymphoma (PEL). The diagnosis of EK-LBL can be challenging due to lack of a clear definition and a consensus diagnostic term. Here, we reviewed 46 such cases with emphasis on the clinicopathologic features.
Design: 46 EK-LBL cases were collected from the English literature (42) or our files (4). All cases had no effusions before or after presentation. Special studies of our cases included immunostains [CD45, CD20, CD79a, PAX5, CD3, MUM1, EMA, CD30, CD138, immunoglobulin (Ig) light chains, and KSHV], EBV(EBER), and T-cell receptor and Ig gene rearrangements. The results were compared with those summarized from 95 PELs in the literature.