A Survey of 45 Biomarkers for Basal-Like Breast Cancer.
Jennifer R Choo, Dongxia Gao, Samuel Leung, Christine Chow, Sherman YH Lau, Jinjin Cheng, Torsten O Nielsen. University of British Columbia, Vancouver, Canada
Background: Basal-like breast cancer was originally identified by gene expression profiling, and it is associated with high-risk disease not responsive to available targeted therapies. Numerous biomarkers for basal-like breast cancer have been proposed. The following study performs a comprehensive immunohistochemical investigation of proposed biomarkers against a gene expression profile gold standard.
Design: Parallel analysis of 45 proposed basal-like biomarkers from literature and gene expression profile data was done on a breast cancer tissue microarray of cases (n = 122) where subtype was previously assigned by a PAM50 gene expression profile gold standard. Twenty-five of the 45 biomarkers were significantly associated with basal-like breast cancer (Table 1). Statistical analysis was performed using the Fisher's exact test corrected for multiple comparisons.