Practical Clinical Application of a Histologic Risk Assessment Model for Head and Neck Squamous Cell Carcinoma.
Robert J Cabay, Tudor Vladislav, Hui Xie, Iffat Choudhry, Steven A Garzon, Vidya Nagrale, Seung Park, Douglas Washing, ShouJin Wu, Yi Zhou, Andre Kajdacsy-Balla. University of Illinois at Chicago
Background: A very promising histologic risk assessment model for head and neck squamous cell carcinoma (HNSCC) has been proposed in which a risk score is derived from the sum of scores for infiltrative pattern, perineural invasion, and lymphocytic response (Brandwein-Gensler et al. Am J Surg Pathol 2005;29:167-178). Risk assessment model validation included live training sessions for the pathologists who applied the model (Brandwein-Gensler et al. Am J Surg Pathol 2010;34:676-688). We questioned whether interobserver agreement would differ if observers applied the model after reading the articles cited above without the benefit of live training sessions, more closely simulating how the model would most likely be implemented in clinical practice.
Design: 6 pathologists and 4 residents at our institution applied the model to 20 cases of HNSCC from our files after learning the scoring method in the model by reading the articles cited above. No training sessions were given. Interobserver agreement was measured using the scores that the observers assigned.
|Observers||Infiltrative Pattern||Perineural Invasion||Lymphocytic Response||Risk Score|
|Pathologists + Residents||0.38||0.49||0.59||0.66|