Relative Survival of Ovarian Surface Carcinoma Subtypes Depends upon Time after Diagnosis.
Meenu Sharma, Mitchell S Wachtel. Texas Tech University School of Medicine, Lubbock
Background: The major subtypes of surface ovarian carcinoma have been compared in multiple studies with respect to survival. Posited was the notion that survival differences of the subtypes might be shown to change as time passed after diagnosis.
Design: The Surveillance, Epidemiology, and End Results Program was queried for women at least 18 years old, with histologically confirmed serous, clear cell, endometrioid, or mucinous carcinoma of the ovary diagnosed between 1988 and 2003, and with at least one month of follow-up, without a prior cancer diagnosis or extra-peritoneal spread at presentation.
Results: Of 10,528 patients, 3,430 (32.6%) experienced cancer related deaths over the first decade. Adjusted for age and race, compared with serous carcinoma, clear cell carcinoma did not prognostically differ during year 1 (Time Ratio=0.84,99% c.i. 0.64-1.14) or years 2-5 (0.84, 0.66-1.1), but did impart a better prognosis during years 6-10 (2.06, 1.27-3.69). Endometrioid carcinoma imparted a better prognosis during year 1 (1.3, 1.01-1.7), years 2-5 (1.92, 1.55-2.44), and years 6-10 (2.28, 1.54-3.37). Mucinous carcinoma did not impart a prognostic difference during year 1 (0.92, 0.69-1.28), but did impart a better prognosis during years 2-5 (2.41, 1.74-3.52) and years 6-10 (8.12, 4.39-19.2). Compared with the clear cell: serous tiime ratio (TR) of year 1, whereas that of years 2-5 (Ratio of TR=1,99% c.i. 0.69-1.5) did not differ, that of years 6-10 (0.41, 0.22-0.7) did. Compared with the endometrioid: serous TR of year 1, those of years 2-5 (0.68, 0.48-0.96) and years 6-10 (0.57, 0.36-0.91) differed. Compared with the mucinous: serous TR for year 1, those of years 2-5 (0.38, 0.24-0.61) and years 6=10 (0.11, 0.05-0.23) differed. By contrast, differences with respect to age and race were not show to vary with respect to years after diagnosis.
Conclusions: Survival differences among surface ovarian carcinoma subtypes depend on time after diagnosis; general statements concerning survival differences are inapt.
Category: Gynecologic & Obstetrics
Tuesday, March 1, 2011 1:00 PM
Poster Session IV # 116, Tuesday Afternoon