Cross-Sectional Study of Cervical Cancer among Hispanic Versus Non-Hispanic White Women Living in the United States.
Edgardo R Parrilla-Castellar, Maria J Merino. National Institutes of Health, Bethesda, MD
Background: Despite advances in early detection and prevention modalities such as the HPV vaccine, cervical cancer continues to be a significant health problem particularly in underdeveloped countries. Changing demographics in the United States underscore the need to delineate variation in cervical cancer outcomes among racial/ethnic groups.
Design: The 1973-2006 National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) dataset was used to analyze clinicopathologic differences in cervical cancer between Hispanic and non-Hispanic white women.
Results: Hispanic women with cervical cancer were younger (mean age 48.1 yrs.) than non-Hispanic white women (mean age 51.1 yrs.)(P<0.001) and less likely to present with advanced stage disease (OR=0.88, P=0.030). Correspondingly, regional lymph node involvement (OR=0.63, P<0.001) and/or distant metastasis (OR=0.68, P=0.001) occurred less frequently among Hispanic women. Whereas squamous cell carcinoma accounted for the most common histology within Hispanic (82%) and non-Hispanic white women (76%), adenocarcinoma was less prevalent among Hispanic women (OR=0.67, P<0.001). Primary-directed surgery was similar between groups (P=0.223). Survival analysis revealed a 23% reduction in risk of dying from cervical cancer (P<0.001) among Hispanic women, whereas multivariate Cox analysis adjusted for age and stage showed Hispanic ethnicity to be an independent predictor of survival (HR=0.79, P<0.001).
Conclusions: Hispanic women with cervical cancer present at an earlier age and have better outcomes than non-Hispanic white women; decreased prevalence of adenocarcinoma among Hispanic women may account for differences in survival. A detailed study will be necessary to elucidate the frequency of aggressive HPV types among Hispanic women.
Category: Gynecologic & Obstetrics
Tuesday, March 1, 2011 9:30 AM
Poster Session III # 212, Tuesday Morning