Stage IIIC Ovarian Cancer-A Heterogeneous Group of Patients with Different Prognosis.
Rania Bakkar, David Gershenson, Elvio Silva. MD Anderson Cancer Center, Houston, TX
Background: Patients suffering from primary ovarian serous carcinoma who present with regional lymph node metastasis without peritoneal involvement outside the pelvis are considered clinically as stage IIIC. Survival of those patients is controversial. We have studied their survival compared to patients with peritoneal involvement beyond the pelvis who are also grouped as stage IIIC. We also included patients with primary peritoneal carcinoma with lymph node metastasis in this study.
Design: Charts of patients with stage III primary ovarian or peritoneal serous carcinoma were reviewed. Patients with primary ovarian serous carcinoma were grouped into patients with lymph node metastasis without peritoneal involvement (group 1, n=13), and patients with ovarian carcinoma with peritoneal involvement beyond the pelvis in addition to lymph node metastasis (group 2, n=43). To compare, group 3 patients (n=38) were selected with similar criteria as group 2 but with negative sampled lymph nodes. Group 4 patients were those with primary peritoneal serous carcinoma with lymph node metastasis (n=13). Median follow up was 72 months (range 1 to 144 months).
|Number of patients||13||43||38||13|
|Number with optimal Tumor Reduction||7 (54%)||26 (60%)||25 (66%)||4 (31%)|
|Number with preoperative Chemotherapy||0||2||3||0|
|Median RFS in months||42||9||12||16|