Prognostic Significance of the 2004 WHO/ISUP Classification for Prediction of Recurrence, Progression and Cancer-Specific Mortality of Non-Muscle-Invasive Urothelial Tumors of the Urinary Bladder: A Clinicopathologic Study of 1515 Cases
CC Pan, HJ Yu, CH Sun. Taipei Veterans General Hospital, Taipei, Taiwan
Background: In order to verify prognostic significance of the 2004 World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grading system, we retrospectively studied 1,515 patients who underwent transurethral resection of primary non–muscle-invasive urothelial tumors (pTa: 1,006 patients; pT1: 509 patients) confined to the bladder.
Design: All cases were reviewed and classified according to the 2004 WHO/ISUP systems as 212 cases of papillary urothelial neoplasm of low malignant potential (PUNLMP), 706 cases of low-grade papillary urothelial carcinoma (LGPUC) and 597 cases of high-grade papillary urothelial carcinoma (HGPUC). Cumulative incidences of recurrence, progression and cancer-specific mortality were compared using univariate and stepwise Cox regression models.
Results: PUNLMP showed the statistically significantly lowest recurrence cumulative incidence compared with the other two tumor types. There were significant differences and trends for higher cumulative incidences progression and cancer-specific mortality in the following order: PUNLMP, LGPUC, pTa HGPUC and pT1 HGPUC. No differences of progression and cancer-specific mortality cumulative incidence were found between pTa and pT1 LGPUC.
Conclusions: A satisfactory prognostic model and nomogram can be developed incorporating 2004 WHO/ISUP grade and stage to predict prognosis of patients with non–muscle-invasive urothelial tumors of the bladder.
Category: Genitourinary (including renal tumors)
Tuesday, March 23, 2010 1:00 PM
Poster Session IV # 96, Tuesday Afternoon