Prostate-Specific Antigen, Prostate-Specific Acid Phosphatase, and Hormone Receptor Expression in Male and Female Breast Carcinoma
TS Kraus, C Cohen, MT Siddiqui. Emory University, Atlanta, GA
Background: Prostate specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are expressed in benign and malignant prostatic tissue. Immunohistochemical staining for these markers can be used to confirm the prostatic origin of metastatic carcinoma. PSA expression has been reported in male and female breast carcinoma and in gynecomastia, raising concerns about the utility of PSA for differentiating prostate carcinoma metastasis to the male breast from primary breast carcinoma. This study examined the frequency of PSA, PSAP, and hormone receptor expression in male breast carcinoma (MBC), female breast carcinoma (FBC), and gynecomastia.
Design: Immunohistochemical staining for PSA, PSAP, AR, ER, and PR was performed on tissue microarrays representing six cases of gynecomastia, thirty MBC, and fifty-six FBC. PSA and PSAP were considered positive if any cytoplasmic staining was observed. Positive reactions for AR, ER, and PR were defined by nuclear staining observed in at least 10% of tumor cells.
|MBC||FBC||Gynecomastia||P-value (MBC vs FBC)|
|PSA||1/30 (3.3%)||2/54 (3.7%)||0/5 (0%)||1|
|PSAP||0/29 (0%)||0/54 (0%)||0/5 (0%)||1|
|AR||20/27 (74.1%)||38/56 (67.9%)||4/5 (80%)||0.62|
|ER||23/37 (85.2%)||37/54 (68.5%)||6/6 (100%)||0.18|
|PR||14/27 (51.9%)||27/57 (47.4%)||5/5 (100%)||0.82|