[826] Soft Tissue Neoplasms of the Male External Genitalia: An Institutional Review of 110 Cases

BC Dickson, DJC Howarth, KPH Pritzker, RA Kandel. Mount Sinai Hospital; University of Toronto, Toronto, ON, Canada

Background: Soft tissue neoplasms involving the female external genitalia have been well-characterized in the literature; however, comparatively less is known about those occurring in adult male counterparts. The purpose of this study was to examine both benign and malignant soft tissue neoplasm affecting the external male genitalia.
Design: We performed an institutional review (1999-2009) to identify all cases of soft tissue neoplasms affecting the penis, perineum, scrotum and spermatic cord.
Results: One hundred and ten soft tissue neoplasms affecting the male external genitalia were identified in the following locations: groin (57), paratesticular region (6), penis (2), perineum (3), pubic region (5), scrotum (10) and spermatic cord (27). The most commonly encountered neoplasms included liposarcoma (23), lipoma (11), pleomorphic undifferentiated sarcoma (11), leiomyosarcoma (9), dermatofibrosarcoma protuberans (8), benign genital stromal tumors [angiomyofibroblastoma and cellular angiofibroma] (7), nodular fasciitis (4), fibrosarcoma (3), synovial sarcoma (3), solitary fibrous tumour (2), angiosarcoma (2), hemangioma (2), low-grade fibromyxoid sarcoma (2) and rhabdomyosarcoma (2). In addition, single numbers of other tumors were also identified. In 11 cases malignant tumors could not be further classified due to the limited size of the biopsy or treatment effect.
Conclusions: Aside from case reports and case series, few reviews exist that characterize the incidence of soft tissue neoplasms involving the male external genitalia. Acknowledging the likelihood of a referral bias for a tertiary care center, we found that both malignant and benign fatty tumors were most commonly observed at this location. Given the substantive number of undifferentiated sarcomas also encountered, it is possible that some of these cases may, in fact, represent dedifferentiated liposarcoma. Tumors within the family of benign genital stromal tumors were noted to have a morphologic and immunohistochemical profile relatively similar to those occurring in females. An awareness for the nature of soft tissue tumors occurring in these locations, along with their potential mimics, is of diagnostic relevance to pathologists and clinicians alike.
Category: Genitourinary (including renal tumors)

Monday, March 22, 2010 1:00 PM

Poster Session II # 94, Monday Afternoon


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