Does the Size Matter? – Prostate Weight Does Not Predict PSA Recurrence after Radical Prostatectomy
DD Davidson, MO Koch, H Lin, L Cheng. Indiana University School of Medicine, Indianapolis, IN; Yale University, New Haven, CT
Background: Previous studies suggest that low prostate weight is a significant negative prognostic guide for prostate cancer assessment. If this observation were sustained by independent clinicopathologic studies, then prostate size would contribute a valuable non-invasive parameter for preoperative patient staging.
Design: 431 men who underwent radical retropubic prostatectomy between 1990 and 1998 were analyzed for association between prostate weight and various clinical or pathological parameters. These included age, preoperative PSA level, PSA recurrence, pathological stage, Gleason grade, extraprostatic extension, positive surgical margins, tumor volume, associated high grade PIN, perineural invasion and lymph node metastasis. Potential associations between evaluated parameters and clinical outcome were probed by Cox regression analysis.
Results: A significant positive correlation was found between prostate weight and increasing patient age or increasing preoperative PSA level. There was no significant independent association between prostate weight and any of the other variables examined, including PSA recurrence. Preoperative PSA and Gleason biopsy grade were significant independent predictors of pathologic stage, Gleason prostatectomy grade, positive surgical margins and PSA recurrence.
Conclusions: Although increasing prostate weight correlates with both increased patient age and higher preoperative PSA level, it does not independently predict favorable postoperative clinical outcome.
Category: Genitourinary (including renal tumors)
Monday, March 22, 2010 1:00 PM
Poster Session II # 129, Monday Afternoon