Utility of Prostatic Fossa Biopsy in Assessing for Locally Recurrent Prostate Carcinoma: Correlation with PSA and Radical Prostatectomy
J Chow, DB Samadi, PD Unger, HJ Lavery, GQ Xiao. Mount Sinai School of Medicine, New York, NY
Background: Early detection of locally recurrent prostatic carcinoma facilitates early salvage therapy. We explore the correlation of prostatic fossa biopsy results with serum prostate-specific antigen (PSA) values and pathology from prior radical prostatectomies.
Design: We reviewed 15 prostatic fossa biopsies obtained status post radical prostatectomy at our institution from 1997 to 2009. We noted the serum PSA value at the approximate time of the prostatic fossa biopsy. Eight available prostatectomy reports were reviewed.
Results: Prostatic fossa biopsy diagnoses, PSA values at the time of biopsy, and pathology of prior radical prostatectomies are summarized in the Table. No patients had evidence of metastases. The range of PSA values was 8.85 to 30.1 ng/ml for the 4 positive biopsies, 0.11 to 3.2 ng/dl for the 7 biopsies containing benign prostatic glands, and 0.24 to 3.78 ng/ml for the 4 biopsies containing benign fibroconnective tissue. Of the 4 positive biopsies, 3 showed greater than 70% tissue involvement and had the highest PSA values. The 1 biopsy with a small focus of carcinoma had the lowest PSA value.
|Patient Biopsy Diagnosis||Serum PSA||Gleason Score||Tumor Stage||Margins||Perineural Invasion||% Tumor Involvement|