Infiltrating Pleomorphic Lobular Carcinoma: High Oncotype DX Score Augments Its "Aggressive" Reputation
SP Salvatore, JS Estrella, H Rennert, SA Hoda. New York Presbyterian Hospital - Weill Cornell Medical Center, New York, NY
Background: Emerging data indicate that the Pleomorphic Variant of Infiltrating Lobular Carcinoma (PV-ILC) has more aggressive potential, and significantly worse recurrence-free survival than the Classical Variant of Infiltrating Lobular Carcinoma (CV-ILC). PV-ILC and CV-ILC share E-cadherin negativity and a common molecular pathway; however, the biological profile of PV-ILC remains relatively unexplored.
Design: Estrogen receptor (ER)-positive breast carcinoma cases with concurrently obtained Oncotype DX® Recurrence Score (ODX-RS) [a 21-gene commercially available molecular test (Genomic Health, Inc, Redwood City, CA)] were categorized for morphological type (ductal versus lobular, confirmed with E-cadherin immunostain) and conventional Nottingham grade(1-3). ODX-RS and 10-year recurrence rate (RR), both as reported by ODX, from patients with PV-ILC were compared to those with CV-ILC and infiltrating duct carcinoma (IDC) of all 3 grades.
Results: The results of 153 ER-positive cases with concurrent ODX-RS and 10-year RR are tabulated below for PV-ILC and CV-ILC, well differentiated-IDC (WD-IDC), moderately differentiated-IDC (MD-IDC), and poorly differentiated-IDC (PD-IDC).
|n||RS||10-year RR||p value|