Cross-Sectional Study of Breast Cancer among Hispanic Women Living in the United States
ER Parrilla-Castellar, D Carter, MJ Merino. National Institutes of Health, Bethesda, MD
Background: Breast cancer is the most common female malignancy. Differences in incidence and mortality between different racial/ethnic groups were recently reported, but not further explored. Changing demographics in the United States underscore the importance of delineating clinicopathologic variation between racial/ethnic groups.
Design: The 1973-2006 National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) dataset was used to analyze clinicopathologic differences in primary tumors of the breast between Hispanic and non-Hispanic white women.
Results: Hispanic women with primary tumors of the breast were younger (mean age 56.9 yrs.) than non-Hispanic white women (mean age 62.2 yrs.)(P<0.001), and were more likely to present with advanced stage disease (OR=1.33, P<0.001). Whereas ductal carcinoma was the most common tumor in both ethnic groups (P=0.100), lobular carcinoma occurred less frequently among Hispanic women (OR=0.86, P<0.001) and medullary (OR=1.40, P<0.001) and inflammatory (OR=1.65, P<0.001) carcinoma occurred more frequently. Hispanic women tended to have tumors with higher-grade morphology (OR=1.16, P<0.001) and were more likely to lack estrogen and progesterone receptor expression (OR=1.32, P<0.001). Multivariate Cox analysis showed Hispanic ethnicity to be a negative independent predictor of survival (HR=1.11, P=0.003).
Conclusions: Hispanic women with breast cancer present at an earlier age and with more advanced stage disease. These data suggest that the initiation of breast cancer screening in Hispanic women at a younger age may help identify a greater number of women with earlier stage disease.
Tuesday, March 23, 2010 9:30 AM
Poster Session III # 31, Tuesday Morning