Increased Length of Survival after Lung Transplantation Is Not Dependent on Patient Age at Transplantation – Analysis of 625 Cases from a Single Center
Z Hu, Y Li, J Gagermeier, C Alex, R Love, M Picken. Loyola University Medical Center, Maywood
Background: Long term survival post lung transplantation (tx) has been increasing with improvments in surgical techniques and immunosuppressive therapies but there is a paucity of data regarding other factors that may determine the outcome.
Design: We analyzed retrospectively 625 patients who underwent lung tx at our institution between 1986 and 2009. To evaluate the trend in survival rate, we grouped the patients chronologically into 3 cohorts: 1986-1990, 1991-2000, and 2001-2009. In order to determine if the recipient's age influenced the outcome of lung tx, the patients were categorized into two groups, Group A (<40 years) and Group B (>=40years). Chi-square test was used to compare the difference in survival rates in different time intervals. Survival estimates were calculated according to the Kaplan-Meier method and curves were compared by the Wilcoxon and log-rank tests.
Results: There were 303 single-, 296 bilateral- and 26 heart-lung tx. The mean age of the recipients was 47.46 ± 13.66 years. Over the three periods studied, there had been a significant improvement in the 1-, 3- and 5-year survival rates for lung tx (p<0.05).
However, there was no signficant difference in survival between younger (< 40 years old) versus older patients (<40 years old) in all three time intervals. Kaplan-Meier survival curves showed no significant difference in post-tx survival time in patients who were < 40 years old versus recipients who were >=40 years (log rank, p =0.19; Wilcoxon, p=0.36).
This suggests that the age of lung recipients per se does not affect the outcome of lung tx.
Conclusions: Survival post lung tx has improved over the last decade. However, younger age of lung tx recipients is not associated with a better outcome of lung tx. Conversely, older patient age, per se, does not appear to affect survival outcome post lung tx.
Tuesday, March 23, 2010 1:00 PM
Poster Session IV # 253, Tuesday Afternoon