t(14;18)-Negative Interdigitating Dendritic Cell Sarcomas: A Morphologic and Immunohistochemical Review
RL Woodford, HY Wang, S Li, SE Mills, JB Cousar. University of Virginia, Charlottesville; UT Southwestern Medical Center at Dallas, Dallas; Emory University, Atlanta
Background: Interdigitating dendritic cell (IDC) sarcomas are exceedingly rare neoplasms that have not been fully characterized. Recent studies have reported rare IDC sarcomas harboring t(14;18) and/or clonal immunoglobulin heavy chain (IGH) gene rearrangements. In contrast, we have previously identified a group of IDC sarcomas that lack both of these molecular findings (manuscript submitted). These disparate results suggest significant molecular heterogeneity within IDC sarcomas. This study used histologic examination and immunohistochemistry (IHC) to evaluate three cases of t(14;18)-negative IDC sarcomas.
Design: Three cases of IDC sarcoma with adequate archival material were available for review. These cases were diagnosed according to the 2008 WHO criteria and were previously shown to be negative for t(14;18) and clonal IGH gene rearrangements. Patient age, sex, and tumor site were noted. Tumor morphology and other histologic features were assessed. IHC and in situ hybridization for EBV-Encoded RNA (ISH-EBER) were performed.
|1||35||M||Left lower quadrant of abdomen|
|2||73||F||Axillary lymph node|
|3||69||M||Parotid gland, level III lymph node|