CD9 and CD38 Expressions Are Significantly Associated with Outcome in Adult Acute Myeloid Leukemia
IN Swati, HK Islam, M Rasul. New York Medical College at Westchester Medical Center, Valhalla, NY; New York Medical College, Valhalla, NY
Background:: Immunophenotypic analysis in acute myeloid leukemia (AML) plays a critical role in the rapid lineage specific diagnosis where as outcome stratification is done by several factors including chromosomal abnormalities. In this study we evaluated the role of immunophenotypic features in determining the outcome of patients in adult AML.
Design: Seventy-five newly diagnosed de novo AML patients, who were diagnosed in our institution between 2006-2008 are included in this study. Immunophenotypic analysis was performed in all cases by a set panel of 30 antibodies by flow cytometry including lineage specific myeloid and lymphoid markers as well as lineage non-specific markers. All the patients were followed from the date of diagnosis to date of progression. All patients were treated with the standard AML treatment regimen and follow up data were available for all cases. Statistical analysis is performed for expression of various markers by using ANOVA in SPSS and was correlated with overall outcome.
Results: CD9 is negatively associated with the disease progression and CD38 expression is positively associated with outcome.
Conclusions: CD9 and CD38 are frequently expressed in AML and are important markers for determination of disease progression.
Tuesday, March 23, 2010 1:00 PM
Poster Session IV # 176, Tuesday Afternoon