Hepatitis C Virus Infection Is Significantly Associated with Malignant Lymphoma in Taiwan, Particularly with Nodal and Splenic Marginal Zone Lymphomas
S-S Chuang, Y-L Liao, S-T Chang, Y-C Hsieh, C-L Lu. Chi-Mei Medical Center, Tainan, Taiwan; Taipei Medical University, Taipei, Taiwan
Background: Hepatitis C virus (HCV) is a hepatotropic and lymphotropic RNA virus contributing to the development of chronic viral hepatitis and hepatocellular carcinoma. HCV is causally linked to non-Hodgkin lymphoma (NHL) with a strong geographic variation. Taiwan is an HCV endemic country without data on the association of HCV and lymphoma to date.
Design: We retrospectively investigated the association of HCV and lymphoma during a 5-year period in Taiwan, a country endemic for HCV, with histopathology, immunohistochemistry, immunoassay and genotyping.
Results: Thirty-eight (11.0%) of 346 lymphoma patients were positive for anti-HCV, in contrast to 3 (1.2%) of 244 healthy controls (p < 0.001, chi-square test) with an odds ratio of 9.91 (95% CI: 3.02 to 34.49). No any specific lymphoma entity was significantly associated with HCV. However, nodal (5 of 8 cases) and splenic (2 of 2) marginal zone lymphomas (MZLs) as a group were significantly associated with HCV infection than mucosa-associated lymphoid tissue (MALT) lymphomas (1 of 15; p = 0.002, Fisher's exact test). All 26 seropositive tumors stained for HCV nonstructural protein 3 were negative. The most common genotypes of these HCV-positive cases were types 1b (22%) and 2a (56%), without statistical significance from that of patients with chronic viral hepatitis C.
Conclusions: HCV infection was significantly associated with lymphoma in Taiwan, with non-MALT MZL (nodal and splenic) as the only group with a statistically significant association. A larger study is needed to see whether any particular HCV genotypes are more closely related to the pathogenesis of lymphoma.
Monday, March 22, 2010 1:00 PM
Poster Session II # 144, Monday Afternoon