Correlation of Microvascular Density (MVD) with Pathological Features and Outcomes of Mucosal Malignant Melanoma (MMM) of the Head and Neck
EH Kerr, D Wang, A Bartolucci, JS Lewis, Jr, N Said-Al-Naief, O Hameed. University of Alabama at Birmingham, Birmingham, AL; Washington University, St. Louis, MO; University of the Pacific, San Francisco, CA
Background: Unlike its cutaneous counterparts, prognostic markers for primary MMM have not been identified. It has been recently demonstrated that MVD in cutaneous MM has a significant negative correlation with survival; however, this has not been well-studied in MMM. This study explores the potential association between MVD, various histological parameters, and the outcome of a series of MMM of the head and neck.
Design: A retrospective search was performed to identify cases of primary MMM of the head and neck at two large university medical centers. All cases were immunostained with CD31 antibody (Dako) using an automated immunostainer (Benchmark XT, Ventana). The MVD was calculated for each case by using the BioquantR Image Analysis software (R&M Biometrics, Nashville, Tennessee).
MVD was then correlated to pathological features of these tumors as previously determined by a detailed clinical and pathological review as well as to outcomes.
Results: Nineteen cases were evaluated, including 16 arising in the sinonasal tract and 3 arising in the oral cavity. The 1 year, 2 year, 3 year, 4 year, and 5 year survival rates were 75%, 57%, 61%, 46%, and 46% respectively. The MVD of the tumors was variable, ranging from 25.7 to 732 vessels/mm2 (mean, 142.8 vessels/mm2; median, 84.7 vessels/mm2). There was no significant correlation between the MVD and different clinicopathological features seen within the tumors, including histologic pattern, mitotic rate, and presence/absence of pigmentation, necrosis, ulceration, or host-associated lymphocytic response. There was also no correlation between the MVD and the lengths of relapse free survival and overall survival.
Conclusions: In contrast to cutaneous melanoma, results of this study suggest that MVD does not correlate with outcome in head and neck MMM. Moreover, there was no association between MVD and particular clinical or pathological features in these tumors. Further larger studies are needed because valid predictive and prognostic markers in head and neck MMM are yet to be determined.
Category: Head & Neck
Wednesday, March 24, 2010 9:30 AM
Poster Session V # 163, Wednesday Morning