Overexpression of Clusterin Is Predictive of Aggressive Biology of Primary Ovarian Cancer
GF Yang, D Xie, Y Liu, YR Lia, WP He, B Fu, CY Fan. The First Affiliated Hospital, Sun Yat-Sen Univ Med Sciences, Guangzhou, China; Cancer Center, Sun Yat-Sen Univ Med Sciences, Guangzhou, China; Guangdong Specialty Hospital of Fertility, Guangzhou, China; Xu Wen Hospitail of Traditional Chinese Medicine, Zhanjiang, Guangdong, China; John L. McClellan Memorial Veterans Hospital and UAMS, Little Rock, AR
Background: Clusterin, a multifunctional glycoprotein, is ubiquitously produced in mammalian tissues. Clusterin has been shown to play significant roles in many aspects of human tumor biology, such as cell proliferation, apoptosis, chemoresistance and angiogenesis. While clusterin is shown to be overexpressed in many types of human malignant tumors, its exact roles in the biologic behavior in ovarian epithelial cancer have not been fully investigated.
Design: Immunohistochemical (IHC) staining for clusterin was performed on a Tissue Microarray (TMA) containing 181 primary ovarian epithelial cancers. These 181 tumors consisted of 119 serous carcinoma, 23 mucinous carcinoma and 39 other types of carcinoma (endometroid, mixed mullerian, clear cell, Brenner, and undifferentiated). The levels of clusterin expression was scored based on staining intensity and percentage of immunopositive cells and were correlated with various clinicopathologic parameters by Chi-square test.
Results: High levels of clusterin protein were seen in 102 of 181 (56%) ovarian epithelial carcinoma. Overexpressed clusterin was significantly correlated with the histologic type of serous carcinoma (p = 0.02), high-grade histology (p = 0.002), and high FIGO stages (p = 0.05).
Conclusions: Overexpression of clusterin gene is commonly detected in primary ovarian cancer and can be used to predict more aggressive biologic behavior of these malignant tumors.
Category: Gynecologic & Obstetrics
Wednesday, March 24, 2010 1:00 PM
Poster Session VI # 162, Wednesday Afternoon