Frequency of Serous Tubal Intraepithelial Carcinoma in Various Gynecological Malignancies – A Study of 290 Consecutive Cases
S Tang, K Onuma, P Deb, E Wang, A Lytwyn, M Sur, D Daya. McMaster University, Hamilton, ON, Canada
Background: Serous tubal intraepithelial carcinoma (STIC) has been reported in association with 32%-46% of pelvic serous carcinoma, suggesting that the tubal fimbria is the primary source of ovarian and peritoneal serous carcinoma. We hypothesized that if this is the case, the frequency of STIC should be substantially lower in endometrial serous carcinomas, in non-serous gynecologic malignancies, and in benign gynecologic neoplasms than in ovarian or peritoneal serous carcinomas.
Design: From 2007-9 the fallopian tubes of 342 consecutive gynecologic cases (269 TAH-BSO, 21 BSO) were entirely submitted for histology using the Sectioning and Extensively Examining the FIMbriated end (SEE-FIM) protocol. This study included 290 of these cases (slides from 16 cases were not available for review and 36 cases only had 1 fallopian tube removed). The slides from the fallopian tubes were independently reviewed by two gynecologic pathologists who were blinded to all other findings; disagreements were resolved by a third pathologist.
|Primary Site||Carcinoma Type||Mean Age||No. Cases||No. (%) STIC|
|Groups||Mean Age||No. Cases||No. (%) STIC|