Vitamin D Receptor Expression in Normal Endometrium and Endometrial Carcinoma. A Tissue-Microarray Study
J Pallares, S Lopez, M Santacana, X Dolcet, JM Valdivielso, J Valls, X Matias-Guiu. Hospital Universitari Armau de Vilanova-IRB, Lleida, Spain
Background: Vitamin D insufficiency has been involved as an etiological agent in different types of tumors, because of its effects in cellular proliferation, apoptosis and angiogenesis. Recent studies have demonstrated an inhibitory effect of Vitamin D in cell proliferation endometrial carcinoma (EC) cell lines with an induction of cell differentiation.
Design: We analyzed the immunohistochemical expression of the Vitamin D receptor (VDR) in two tissue microarrays (TMA). One constructed from 80 samples of normal endometrium in different phases of the menstrual cycle and a second TMA containing 62 ECs with different histological types, FIGO grades and pathological stages.
Results: In normal endometrium (NE) VDR expression was very significantly reduced in the proliferative phase (mean: 190.76) compared with the secretory phase (mean: 214.39) (p = 0.006). EC showed a significant reduction in VDR expression compared with its expression in normal endometrium (mean EC: 181.7, mean NE: 207.7) (p = 0.001). No differences were observed in the VDR expression in different types of EC (mean endometrioid type: 181.30, mean non-endometrioid type: 183.88) (p = 0.99), histological grade (mean grade I: 177.06, grade II: 189.55 and grade III: 176.33) (p = 0.43) or with pathological stage (p = 0.18).
Conclusions: VDR expression is significantly reduced in the proliferative endometrium and endometrial carcinoma and could have a role in endometrial cell carcinogenesis by controlling mechanisms involved in cell proliferation.
Category: Gynecologic & Obstetrics
Wednesday, March 24, 2010 9:30 AM
Poster Session V # 137, Wednesday Morning