Differential Nuclear Expression of Aurora A Kinase in Benign, Borderline, and Malignant Serous Ovarian Tumors
JE Crane, DS Schultz, KV Inamdar, NL Lehman. Henry Ford Hospital, Detroit, MI
Background: Aurora A is a serine/threonine kinase important in mitosis. It has been implicated in the tumorigenesis of several malignant neoplasms, including breast, colorectal, pancreas, and ovary (Sasayama T, et al. Genes Cells 2005;10:627). It has been suggested that aurora-A expression may also have prognostic value in ovarian carcinoma (Mendiola M, et al. Hum Pathol 2009;40:631).
Design: We investigated the expression of aurora A by immunohistochemistry in 10 benign serous cystadenomas, 8 serous borderline tumors, and 12 malignant serous ovarian tumors.
Results: All 10 benign neoplasms (100%) showed moderate to strong nuclear immunoreactivity for aurora A. No perinuclear cytoplasmic staining was demonstrated. Sixty-three percent (5/8) of the borderline tumors demonstrated weak to moderate nuclear staining. The remaining borderline tumors (38%, 3/8) were negative for aurora A. Twenty-five percent (3/12) of the malignant tumors demonstrated perinuclear cytoplasmic staining for aurora A, ranging from weak to strong. All malignant tumors lacked nuclear aurora A positivity (100%). Using Fisher's Exact Test the results were found to be statistically significant when the tumor grade (benign/borderline/malignant) was analyzed against the staining pattern (absent/cytoplasmic/nuclear) or staining intensity (weak, moderate, strong) (p < 0.01).
Conclusions: Our results show that benign serous ovarian tumors show strong nuclear staining, which is completely absent in malignant tumors. Borderline tumors tend to show nuclear staining like benign tumors, albeit generally weaker, but sometimes lacked nuclear staining like malignant tumors. This data may thus be of potential value in predicting the behavior of borderline tumors. The overall results of negative nuclear aurora A expression in malignant tumors may have important implications in the biology of ovarian serous tumors. Further studies of the possible clinical implications of the loss of nuclear aurora A expression in some borderline serous tumors, and the role of that loss in ovarian serous carcinogenesis are warranted.
Category: Gynecologic & Obstetrics
Monday, March 22, 2010 9:30 AM
Poster Session I Stowell-Orbison/Surgical Pathology/Autopsy Awards Poster Session # 150, Monday Morning