New Antibodies for Clear Cell Carcinoma (Pax-8, HNF-α, vHL) Are Also Positive in Arias-Stella Reaction
CE Aguilar, E Silva. Cedars-Sinai Medical Center, Los Angeles, CA
Background: Recent studies have shown clear cell carcinoma of müllerian origin to be positive for Pax-8, hepatocyte nuclear factor- α (HNF-α), and von Hippel Lindau (vHL). Clear cell carcinoma of müllerian origin can present a diagnostic challenge in endometrial specimens showing areas of Arias-Stella. Therefore, Pax-8, HNF-α, vHL were applied to products of conception showing areas of Arias-Stella reaction.
Design: Ten products of conception specimens showing Arias-Stella reaction and ten cases of clear cell carcinoma were stained with Pax-8, HNF-α, vHL.
Results: In all ten cases, Arias-Stella cells and secretory glands displayed Pax-8 and HNF-α nuclear positivity and vHL cytoplasmic staining. All three immunostains were positive in each case of clear cell carcinoma with the expected pattern of staining.
Conclusions: Clear cell carcinoma antibodies, Pax-8, HNF-α, and vHL, are positive in Arias-Stella reaction. These antibodies therefore cannot be applied to endometrial specimens in which the differential diagnosis includes clear cell carcinoma and Arias-Stella reaction. Future immunohistochemical studies to determine whether other molecular targets involved in the clear cell carcinoma pathway(s) can also be detected in Arias-Stella reaction would be useful in this unusual but challenging and important distinction.
Category: Gynecologic & Obstetrics
Wednesday, March 24, 2010 9:30 AM
Poster Session V # 128, Wednesday Morning