Characterization of Bone Tissue in the Ovary
C Habib, QJ Cao, CN Otis, L Pantanowitz. Baystate Medical Center/Tufts University School of Medicine, Springfield, MA
Background: The occurrence of bone in the ovary is uncommon. To date, there have been no series investigating this finding. The aim of this study was to characterize the various bone types and their associations as found in a large series of ovaries.
Design: Archival cases of oophorectomy in which bone was reported were studied. Patient age, associated ovarian pathology, unilateral or bilateral involvement, bone type (benign/malignant, woven/lamellar, spongy/cortical) and activity (osteoblastic/osteoclastic) were documented and collated.
Results: We identified 25 cases from patients with a mean age of 38 years (range, 6 to 84 years). Bone was noted on gross examination in 16 (64%) cases. Benign osseous metaplasia was seen in 14 (56%) cases with either fibromas, endometriosis, fibrosis, follicular cysts, or a remote corpus albicans. Cortical-type bone was associated with 11 (44%) mature teratomas. Lamellar bone alone was seen in 17 (68%) cases, woven bone in 2 (8%) cases, and both types of bone identified in 5 (20%) cases. Osteosarcoma was present in 1 (4%) case of heterologous-type malignant mixed mllerian tumor. Associated cartilage (7 cases) and marrow (3 cases) were seen only in teratomas. Osteoblastic activity occurred in 9 (36%) cases, of which 8 were teratomas.
Conclusions: Bone may form in the ovaries of patients of all ages. In most cases heterotopic bone is of lamellar type. When present, bone is likely to be associated with either a metaplastic process (56%), mature teratoma (44%), or in rare cases a malignant mixed mllerian tumor (4%).
Wednesday, March 11, 2009 9:30 AM
Poster Session V # 128, Wednesday Morning