[979] Significant Differences in Tumor Cell Type in Early Versus Advanced Stage Ovarian Carcinoma
CB Gilks, M Kobel, SE Kalloger, DG Huntsman, J Santos, N Le, K Swenerton. University of British Columbia, Vancouver, BC, Canada; British Columbia Cancer Agency, Vancouver, BC, Canada
Background: Most patients with ovarian carcinoma present with advanced stage disease. It has been inferred that early detection can significantly impact on mortality due to ovarian cancer, as patients who present with early stage disease have dramatically better prognosis than patients with advanced stage tumors. While there are recognized differences between those tumors diagnosed at early versus advanced stage, there is a lack of data on stage distribution of ovarian carcinomas from large population-based cohorts, whose cell type assignment has been done, based on current diagnostic criteria.
Design: We reviewed cases of ovarian carcinoma referred to the British Columbia Cancer Agency over a 16 year period (1984-2000) to characterize differences in tumor cell type between early and advanced stage tumors. Slides were reviewed centrally and tumors assigned to one of six tumor cell types (clear cell, endometrioid, mucinous, low-grade serous, high-grade serous, carcinoma NOS), without knowledge of patient outcome.
Results: Tumor cell type distribution in early and advanced stages is presented in the Table.
Portion of Tumor Cell Types in Early and Advanced Stages| Stage | High-grade serous | Clear cell | Endometrioid | Mucinous | Low-grade serous | NOS | Stage | | I/II | 30.0% | 26.2% | 29.4% | 8.5% | 1.9% | 4.0% | 25% | | III/IV | 84.2% | 4.9% | 3.5% | 1.1% | 4.9% | 1.4% | 75% | | All | 70.0% | 10.4% | 10.3% | 3.6% | 3.5% | 2.1% | 100% | NOS - not otherwise specified
Conclusions: The distribution of tumor cell types differs in patients with early versus advanced stage ovarian carcinoma. This has broad implications, particularly for early detection and screening of ovarian carcinoma and studies on treatment of early stage ovarian carcinoma.
Category: Gynecologic
Wednesday, March 11, 2009 9:30 AM
Poster Session V # 135, Wednesday Morning
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