Prevalence and Genotype Identification of HPV Infection in a Population of Turkish Women
F Eren, M Erenus, E Bas, R Ahiskali, T Yoldemir. Marmara University School of Medicine, Istanbul, Turkey
Background: Infection with certain types of HPV is a very important risk factor for cervical carcinoma. Type specific distribution of HPV differs among regions around the world and epidemiological distribution of HPV in a given area is important for both developing health policies and success of vaccination programs. The aim of this study was to evaluate the prevalence of the different HPV genotypes in a population of Turkish women referring to gynecological outpatient clinics which will provide valuable information for developing future management and prevention policies.
Design: A total of 408 women (age range: 19-70) referred to gynecology outpatient clinics of a university hospital (Marmara University) and an affiliated private institution (Academic Hospital) were recruited from May 2008-August 2008. Split sampling was used for obtaining specimens for cytological examination. HPV typing were identified by PCR DNA microarray method which enables identification of 35 types. HPV typing and cytological examination were blinded.
Results: The overall prevalence of HPV was found to be 16 % (67of 408) with 75% being in the high risk group. Type 16 was the most frequent HPV type (23%) followed by types 53 (13%), 6(12%), 58 (10%) and 66 (10%). Multiple genotypes were found in 22%. 82% (55 of 67) of HPV positive women had normal cytology; 10% have LSIL; 4% and 3% have ASCUS and HSIL respectively. It was the first time screening for 33% of HPV positive women. The highest prevalence was observed in women aged 20-30 years (38%), followed by women aged 31-40 (32%) and over 40 (30%). Overall prevalence was similar among women referring to both institutions.
Conclusions: This study showed that HPV infections in our population has a wide age distribution and involve numerous types including those not present in the commercially available vaccine, even in patients with no evidence of cytological alterations in cervical cells. These findings will provide an important data for both epidemiological HPV profile and determining the future impact of vaccines.
Monday, March 9, 2009 1:00 PM
Poster Session II # 134, Monday Afternoon