Warty/Basaloid (Undifferentiated) Penile Intraepithelial Neoplasia (PeIN) Is More Prevalent Than Differentiated PeIN in a Non-Endemic Region for Penile Cancer When Compared with an Endemic Area. A Comparative Study between France and Paraguay
A Soskin, A Vieillefond, A Carlotti, F Plantier, A Chaux, G Ayala, EF Velazquez, JJ Torres, AL Cubilla. Hospital Cochin, Paris, France; Baylor College of Medicine, Houston, TX; Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Instituto de Patologia e Investigacion, Asuncion, Paraguay
Background: PeINs are classified in undifferentiated (warty/basaloid) and differentiated in concordance with their HPV related and HPV unrelated pathogenesis. High incidence of HPV- related PeIN have been reported in European countries but we found no comparative study with other regions.
Design: To test the hypothesis of a higher incidence of HPV related PeIN in geographical regions non endemic for penile cancer we standardized diagnostic criteria and compared 1- penile precancerous lesions from 78 and 25 patients from France (non-endemic) and Paraguay (endemic for penile cancer). 2- PeIN associated with invasive carcinoma from 37 and 73 patients from Paris and Paraguay. Eighteen cases of PeIN not fitting into these 2 categories were excluded from the study.
|PeIN||PeIn alone||PeIn with invasive cancer|
|France (%)||Paraguay (%)||France (%)||Paraguay (%)|
|Diff||8 (10)||16 (64)||18 (49)||57 (78)|
|Undiff||70 (90)||9 (36)||19 (51)||16 (22)|
|Total||78 (100)||25 (100)||37 (100)||73 (100)|
Conclusions: HPV- related undifferentiated PeIN was more prevalent in European patients (90 vs. 36%, p < 0.000001; and 51 vs. 22 %, p <0.004). This is in contrast to the higher frequency of HPV unrelated invasive tumors reported in European, North American and South American patients. Possible explanations may be the higher prevalence of HPV types pathogenetically related to PeIN in the European study population or the clinical under recognition of differentiated lesions.
Category: Genitourinary (including renal tumors)
Tuesday, March 10, 2009 1:00 PM
Poster Session IV # 118, Tuesday Afternoon