[601] Survival by Depth of Tumor Invasion in PT1 Esophageal Adenocarcinoma: An Analysis of 182 Patients
DK Kaneshiro, JC Post, LA Rybicki, TW Rice, JR Goldblum. Cleveland Clinic, Cleveland, OH
Background: Duplication of the muscularis mucosa (MM) is a known finding in Barrett's esophagus. Few studies have evaluated the relationship between depth of invasion in intramucosal carcinoma (IMC) and survival in a large group of pts.
Design: 182 pts with pT1 esophageal adenocarcinoma treated by esophagectomy (no induction therapy) were identified. IMC was subdivided into invasion into lamina propria (LP), inner muscularis (IMM), between inner and outer MM (BMM) and outer muscularis (OMM) and compared to tumors invading the inner third of the submucosa (SM-I). Gender and pathologic N-stage were compared among the five groups using Chi-square test. Age and yrs follow-up were compared among groups using the Kruskal-Wallis test. Survival was estimated using the Kaplan-Meier method and compared among the five groups using the log-rank test.
Results: For IMC, depth of invasion was LP (n=69), IMM (n=36), BMM (n=12), OMM (n=32). 33 pts had SM-I. Pt characteristics are summarized in Table 1. Length of survival by group is summarized in Figure 1. There was no significant difference in gender or age among groups. 3/149 pts with IMC had N1 disease (2%; LP-2, BMM-1). 2/33 pts with SM-I had N1 disease (6%).
| Group (N) | Male | Mean Age SD (R) | pN0 | pN1 | Mean yrs follow upSD (R) |
| All pts (182) | 156 (85.7%) | 6310 (35-81) | 177 (97.3%) | 5 (2.7%) | 5.94.7 (0.1-20.5) |
| LP (69) | 56 (81.2%) | 6210 (42-79) | 67 (97.1%) | 2 (2.9%) | 6.04.3 (0.1-20.5) |
| IMM (36) | 32 (88.9%) | 6411 (35-79) | 36 (100%) | 0 | 4.94.0 (0.2-12.6) |
| BMM (12) | 10 (83.3%) | 6110 (48-74) | 11 (91.7%) | 1 (8.3%) | 5.64.7 (0.2-14.8) |
| OMM (32) | 30 (93.8%) | 6311 (36-80) | 32 (100%) | 0 | 6.86.1 (0.1-20.4) |
| SM-I (33) | 25 (84.8%) | 669 (48-81) | 31 (93.9%) | 2 (6.1%) | 6.14.6 (0.1-16.6) |
| P-value | 0.52 | 0.51 | 0.32 | 0.32 | 0.85 |
Conclusions: Depth of invasion within IMC does not impact survival. SM-I pts had similar survival to those with IMC-OMM.
Category: Gastrointestinal
Wednesday, March 11, 2009 1:00 PM
Poster Session VI # 97, Wednesday Afternoon