Expression of CDK-2 in Psoriasis
A Santos-Briz, P Antunez, M Roncero, E Fernandez, A Bullon, P Unamuno. Hospital Universitario de Salamanca, Salamanca, Spain
Background: Psoriasis is a chronic inflammatory skin disease characterized histologically by hyperproliferation and aberrant differentiation of epidermal keratinocytes. It is known that Cyclin-dependent kinase 2 (CDK2) plays an important role in keratinocyte proliferation. The aim of our study was to evaluate the expression of CDK-2 in cutaneous specimens of patients with psoriasis and compare it with normal skin and other inflammatory dermatosis.
Design: The immunohistochemical expression of CDK-2 was evaluated in cutaneous biopsies from a group of 71 patients with psoriaris, 18 of them with palmoplantar psoriaris. Results were compared with the expression of CDK2 in normal skin (n=40), eczema (n=28), cutaneous lupus erythematosus (n=16), pityriasis rosea (n=10), and chronic lichenoid pityriasis (n=11). For our purpose a high throughput Tissue Microarray strategy was designed.
Results: Increased expression of CDK2 was found in the upper layers of the lesional psoriatic epidermis compared to epidermis in both normal skin and other inflammatory dermatosis (p<0,001). Expression also differed among conventional psoriasis and palmoplantar psoriasis (p<0,001). CDK2 expression was found in 66% of psoriasis, 11.8% of palmoplantar psoriaris, 25.9% of eczemas, 0% of cutaneous lupus erythematosus, 10% of pityriasis rosea , 9.1% of chronic lichenoid pityriasis and 9% of normal skin samples.
Conclusions: Our results suggest that CDK2 plays an important role in keratinocyte proliferation in psoriasis. Moreover, differences between the expression of conventional psoriasis and palmoplantar psoriasis specimens suggest a different pathogenesis of both diseases.
Tuesday, March 10, 2009 1:00 PM
Poster Session IV # 74, Tuesday Afternoon