[371] Adenocarcinoma in Papanicolaou Specimens from Patients with Endometrial Carcinoma: Correlation with Tumor Stage and Endocervical Involvement

K Garg, R Feratovic, O Lin. Memorial Sloan Kettering Cancer Center, New York, NY

Background: Atypical glandular cells can be found in Papanicolaou specimens from patients with endometrial carcinomas (EC). The extent of surgery in endometrial adenocarcinomas depends on the stage of the endometrial carcinoma. The stage can sometimes only be determined intraoperatively and the accuracy of this evaluation is variable. We propose to evaluate the correlation between the presence and number of atypical glandular cells in Papanicolaou smears with stage. The findings might be helpful in determining surgical management. We also proposed to evaluate the same criteria to determine if there was any correlation with endocervical involvement.
Design: We reviewed our database to identify cases of ECs where the preoperative Papanicolaou specimens showed the presence of atypical glandular cells. The specimens were evaluated to confirm the presence of atypical cells similar to the ones seen in the tissue sections. The number of cells was recorded and correlated with the tumor stage and endocervical involvement by EC.
Results: A total of 36 cases of EC met the above criteria. The relationship between tumor stage and number of atypical cells in the Papanicolaou specimen is shown is Table 1. More than 10 atypical cells in Papanicolaou specimens is noted in 32% of the stage I EC, while 50% or more cases of stage II-IV also showed increased number of atypical glandular cells.

Table 1

Stage/number of cells	1-10 cells	>10 cells
I	17	8
II	0	3
III	4	4
IV	1	2

The correlation between endocervical involvement and number of atypical cells in the Papanicolaou specimen is summarized in table 2. More than 10 atypical cells was noted in 37% of cases without endocervical involvement by EC and in 78% of cases with endocervical involvement by EC.

Table 2

Endocervical involvement/number of cells	1-10 cells	>10 cells
No	19	11
Yes	2	7

Conclusions: Although the Papanicolaou specimens are not a sensitive screening test for EC, the presence of increased number of atypical glandular cells in Papanicolaou specimens from patients with EC is associated with higher tumor stage and endocervical involvement.
Category: Cytopathology

Wednesday, March 11, 2009 9:30 AM

Poster Session V # 37, Wednesday Morning