Survey of Coronary Artery Atherosclerosis among 40-54 Year Old Normal Weight and Obese Patients: An Autopsy Based Study
AW Wilhorn, DV Miller. Mayo Clinic, Rochester, MN
Background: Ischemic heart disease and coronary atherosclerosis remains the leading cause of death in the United States. Obesity is a recognized independent risk factor for atherosclerosis in general, but there are few recent data on associations between obesity and coronary artery atherosclerosis specifically.
Design: This study included a retrospective review of autopsy reports from 2003-2008 to abstract manner and cause of death, body weight and height, age, and degree of coronary atherosclerosis in each coronary vessel. Coronary atherosclerosis was graded as 1: <25%, 2: 26-50%, 3: 51-75% and 4: >75% luminal occlusion. Patients between the ages of 40-54 to focus on a population segment at risk for coronary disease and likely to be of stable body weight (without age-related loss of muscle mass).
Normal Weight Patients (BMI= 18.5-24.9)*p<0.001
|Average LAD Disease Grade:||2.13*|
|Average LCX Disease Grade:||1.73*|
|Average RCA Disease Grade:||2.03*|
|% with Severe 3-vessel Disease:||7%|
|% with at least 1-vessel Severe Disease:||32%|
|Cardiac Related Cause of Death:||19%|
Obese Patients (BMI= 30.0-39.9)*p<0.001
|Average LAD Disease Grade:||2.62*|
|Average LCX Disease Grade:||2.11*|
|Average RCA Disease Grade:||2.32*|
|% Severe 3-vessel Disease:||12%|
|% with at least 1-vessel Severe Disease:||35%|
|Cardiac Related Cause of Death||27%|
Conclusions: While overall the average difference in coronary atherosclerosis severity in a given artery as well as the overall incidence of severe single vessel disease showed only minor (but statistically significant) differences among the obese and normal body weight groups, there was a substantial increase in severe 3 vessel disease with obesity. Cardiac related causes of death were also more common in the obese group.
Monday, March 9, 2009 8:45 AM
Platform Session: Section H1, Monday Morning