Incidence of Brain Malformations. A Study of 395 Perinatal Autopsies
JC Mantilla, JA Diaz, LP Herrera. Universidad Industrial de Santander, Bucaramanga, Santander, Colombia; University of Miami, Miami, FL
Background: Brain malformations are common congenital malformations, with diverse morphological and etiopathogenic features. The aim of this study is to determine the frequency and clinicopathological features of brain malformations in a tertiary care center.
Design: A prospective study was conducted from March 2004 to February 2008 of patients that underwent perinatal autopsy performed at the Hospital Universitario de Santander, Colombia.
Results: During the length of the study 395 perinatal autopsies were performed. The average gestational age was 29.4 weeks, with a range between 12 to 42 weeks. The male: female ratio was 1.2:1. Congenital malformations or dysmorphic features were present in 64 (16%) of cases.Twenty seven (7%) patients had brain malformations, of these 9 had hydrocephalus (2.2%), 7 holoprosencephaly (1.8%), 6 anencephaly (1.5%), 2 agenesis of the corpus callosum (0.5%), 1 agenesis of brain stem (0.2%), 1 acrania (0.2%) and 1 microphthalmia (0.2%).
Conclusions: Central nervous system malformations are common amongst patients with congenital malformations. Hydrocephaly and holoprosencephaly are the most common types observed.
Wednesday, March 11, 2009 1:00 PM
Poster Session VI # 4, Wednesday Afternoon