Outcome of Papillary Carcinoma of Breast, One Institutional Experience
C Cookingham, X Jing, D Vishcher. University of Michigan Health Syatem, Ann Arbor, MI
Background: Papillary carcinomas of breast are uncommon; there are limited data regarding pathologic characteristics and outcomes. It has also been noted that distinguishing among intracystic papillary carcinoma, intracystic papillary carcinoma with invasion and invasive papillary carcinoma can be challenging. The aim of this study is to describe natural history of papillary carcinoma and its long-term prognosis.
Design: The cases with diagnoses of intracystic papillary carcinoma with or without invasion, invasive papillay carcinoma including solid papillary carcinoma variant were included in this study. The cases were retrieved through a search of the departmental database in the period of 1990-2006. The medical records were retrospectively reviewed with regard to clinical history, pathologic finding, treatment approach and outcomes (mean 7.1 years follow-up).
Results: The study involved total of 25 women with an average of 63 (41-84) years old. Eighteen patients had pure papillary carcinoma and 10 had invasion. Seven patients had papillary carcinoma with coexisting in-situ and/or invasive ductal or lobular carcinoma with three of them having invasive papillary carcinoma. Tumor size measured from 0.5 to 4.2 cm. ER was positive in 86.7%. Her-2/neu was tested in 8 patients and all were negative. Triple-negative receptor status was observed in one patient. Treatment involved combination of surgery, tamoxifien and radiation, as well as surgery and/or chemotherapy and radiation. Nodal status was assessed in 10 patients and metastasis was seen in two patients with pure invasive papillary carcinoma. These two patients were tumor-free for 3 and 18 years, respectively. Distant metastasis was observed in only one case, at year six of follow-up in a patient with nodal negative mixed papillary ductal carcinoma.
Conclusions: Although a small-scale study, the above data support the theory that papillary breast carcinomas has an indolent natural history and should be distinguished from tumors with ductal phenotype.
Tuesday, March 10, 2009 1:00 PM
Poster Session IV # 13, Tuesday Afternoon