Lymphoepithelioma-Like Carcinomas in the Uterine Cervix and Endometrium: A Clinicopathologic Study of 6 Cases with Evaluation of Epstein-Barr Virus and Human Papilloma Virus Genomes
JS Song, J Choi, YH Lee, KR Kim. University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
Background: Lymphoepithelioma-like carcinomas (LELC) have been reported in many sites, including nasopharynx, salivary gland, thymus, stomach, breast, and uterine cervix. Lymphoepithelial carcinoma occurring in nasopharynx is known to be strongly associated with Ebstein-Barr virus (EBV) and the prognosis is favorable, but the causative relationship of oncogenic virus and the prognosis of LELC in other areas are poorly defined.
Design: To evaluate the pathogenetic significance of EBV and human papilloma virus (HPV) infections in LELC in the female genital tract, we performed in situ hybridization for EBV and genotyping DNA chip analysis for HPV in 6 cases of LELCs occurring in the uterine cervix and endometrium using paraffin embedded tumor tissue, which we have experience during twelve years.
Results: Two cases showed EBV genome and one had HPV genome of high risk type (type 16). FIGO stages were IB1 (n=2), IB2 (n=2), III (n=1), and IVB (n=1). Five tumors in the uterine cervix were composed of medullary carcinoma-like nests, and one endometrial carcinoma showed adenocarcinomatous differentiation, both of which were surrounded by dense lymphoplasmacytic infiltrates. One cervical cancer patient (FIGO stage IVB) died of disease, and four patients had no evidence of disease during the follow-up period (mean: 33months, 3-70 months).
Conclusions: LELC can be associated with either EBV or HPV infection, but their causative relationship was not clearly identified.
Monday, March 9, 2009 1:00 PM
Poster Session II # 148, Monday Afternoon