Anal Pap Smears Frequently Show Abnormalities in HIV-Positive Women
N Roche, P Isedeh, O Kuye, DS Heller. UMDNJ-New Jersey Medical School, Newark, NJ
Background: Over the past 20-30 years, the incidence of squamous cell cancer of the anus in the United States has increased by about 96% in men, and 39% in women. With cytology screening, anal squamous cell carcinoma may be one of the few preventable malignancies in HIV-positive individuals, who are at high risk of anal disease. This study evaluated prevalence of positive anal pap smears, and association with the cervicovaginal findings in HIV+ women.
Design: This retrospective study identified HIV+ women who had cervical or vaginal pap smears at an Infectious Disease Clinic between January 1, 2006 and June 30, 2007. Anal pap data was compared to cervicovaginal results.
Results: 200 anal pap smears were included in the study. 20 were unsatisfactory, leaving 180 for analysis. 35 out of 180(19.4%) of anal pap smears were abnormal. 65 out of 200 patients(32.5%) had abnormal cervical or vaginal pap smears. Of the 35 abnormal anal paps, 28 also had an abnormal cervicovaginal pap. 7 of the 35 had a normal cervical pap, so would have been missed if anal screening had been restricted to only patients with abnormal cervicovaginal cytology.
Conclusions: Anal pap smear abnormalities are common in HIV+ women, particularly those with an abnormal cervical or vaginal pap. For high risk populations, it is reasonable to perform anal pap screening.
Monday, March 9, 2009 1:00 PM
Poster Session II # 126, Monday Afternoon