Cross-Sectional Study of Ovarian Tumors among Hispanic Women Living in the United States
ER Parrilla Castellar, MJ Merino, TP Diaz-Montes. NIH, Bethesda, MD; Johns Hopkins Medical Institutions, Baltimore, MD
Background: The prevalence of primary tumors of the ovary in the Hispanic female population living in the United States remains unexplored.
Design: The National Cancer Institute's Surveillance, Epidemiology, and End Results Program (SEER) was used to identify 4,159 Hispanic (Hisp.) and 43,867 non-Hispanic white (NHW) women diagnosed with a primary ovarian tumor from 1973 to 2004. Data derived from this registry was analyzed for differences in demographic characteristics and clinico-pathologic features.
Results: Hispanic women diagnosed with ovarian tumors were younger at presentation than NHW women (51 years vs. 59 years, P<0.001). They were also more likely to present with early stage (I/II) disease (OR=1.23, P<0.001). Epithelial tumors occurred in 94% of NHW women and 88% of Hispanic women (OR=0.49, P<0.001). When presenting with an epithelial neoplasm, Hispanic women were almost twice as likely as NHW women to have tumors of borderline malignant potential (17% vs. 10%, OR=1.98, P<0.001). Germ cell and sex-cord tumors were more prevalent in Hispanics than NHW women (8% vs. 3%, OR=3.48, P<0.001 and 2% vs. 1%, OR=1.44, P<0.001, respectively). Therapeutic surgical interventions was similar between the two groups (94% vs. 94%, P=0.353). Kaplan-Meier analysis showed increased overall survival for Hispanic women (mean 182 months vs. 145 months, P<0.001). Univariate Cox survival model revealed a 27% reduction in risk of dying from any cause among Hispanic women compared to NHW women diagnosed with a primary ovarian tumor (P<0.001).
Conclusions: Hispanic women diagnosed with primary ovarian tumors present at an earlier age and stage compared to non-Hispanic white women. Epithelial tumors are less prevalent among Hispanic women and are more likely to be of borderline malignant potential. Alternatively, germ cell and sex-cord tumors occur at a greater frequency in Hispanic women. These factors may account for increased survival among Hispanic cohorts. The basis for these differences need to be further studied. Collectively, the data presented here help define ovarian tumors among the Hispanic female population living in the United States.
Wednesday, March 11, 2009 9:30 AM
Poster Session V # 133, Wednesday Morning