[2370.6] Urinary Phthalates Are Associated with Increased Blood Pressure in Childhood
Leonardo Trasande, Sheela Sathyanarayana, Adam J. Spanier, Teresa M. Attina, Elaine M. Urbina. Pediatrics, NYU School of Medicine, New York, NY; Pediatrics, University of Washington, Seattle, WA; Pediatrics, Penn State University, Hershey, PA; Preventive Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
BACKGROUND: Exposure to phthalates, a diverse group of environmental chemicals, is associated with increased adiposity and insulin resistance. Associations with other adverse cardiometabolic outcomes that are increasing in prevalence among US children are plausible, but have not been studied in children.
OBJECTIVE: To examine associations between urinary phthalates and cardiometabolic outcomes in children.
DESIGN/METHODS: We performed a cross-sectional analysis of 2247 US children 6-19 years of age who participated in the National Health and Nutrition Examination Survey between the years 2003-2008. We quantified exposure to three families of phthalates (low-molecular weight (LMW), high-molecular weight (HMW) and di-2-ethylhexylphthalate (DEHP) based on molar concentration of urinary metabolites. We assessed descriptive, bivariate and multivariable associations with blood pressure and lipids.
RESULTS: The study population was 51.8% male, 35.5% overweight, and 7.3% prehypertensive, all nearly identical to the entire NHANES. Chi-square testing revealed no significant demographic differences between children and adolescents with measured phthalate concentrations and children without measurements. Median LMW, HMW and DEHP concentrations were 0.884, 0.491 and 0.337 molar. 5.1% of children had
CONCLUSIONS: Dietary phthalate exposure is associated with increases in blood pressure in children and adolescents. Further work is needed to confirm these associations, and to assess opportunities for intervention.
Session: Platform Session: Hypertension: Latest Insights on Current Work (10:30 AM - 12:30 PM)
Date/Time: Sunday, May 5, 2013 - 11:45 AM
Room: 203 - Walter E. Washington Convention Center
Course Code: 2370