Characteristics and Survival of Patients with the Total Artificial Heart Implanted for Indications Other Than Biventricular Failure
K.L. Thanavaro, D.G. Tang, R.H. Cooke, A.C. Mankad, M.L. Hess, V. Kasirajan, K.B. Shah. Departement of Internal Medicine, Division of Cardiology, VCU Medical Center, Richmond, VA; Department of Cardiothoracic Surgery, VCU Medical Center, Richmond, VA
Purpose: Total heart replacement with the artificial heart (TAH) is an effective bridge to transplant for patients with primary biventricular heart failure (BiVHF). We sought to characterize our experience with the TAH in patients with alternate indications (ALT) other than BiVHF.
Methods and Materials: We conducted a single-center retrospective study of 66 patients who received the TAH from 2006-2012. The baseline characteristics of patients in each group are analyzed with a chi-squares and two-sample independent t-test. Survival to transplant is evaluated with a Cox regression and Kaplan-Meier analysis.
Results: 26 of the 66 patients (39%) received the TAH for ALT, which included: hypertrophic cardiomyopathy (n=2), refractory arrhythmias (n=8), acute shock (n=6), ventricular rupture (n=2), LVAD failure (n=3) and cardiac allograft failure (n=5). Though the ALT patients trended toward INTERMACS profile 1 (50% vs 35%, p= 0.2), we found no statistically significant difference in baseline characteristics or laboratory values between ALT vs BiVHF.
|Total bilirubin (mg/dL)||1.8||1.5||0.2|
|Mean RA (mm Hg)||19.3||15.9||0.2|
|Mean PAP (mm Hg)||39.8||31.9||0.07|
|PCWP (mm Hg)||28.8||23.6||0.08|