[2009] [FRI0329] BONE MINERAL DENSITY PARAMETERS IN A GROUP OF FEMALE PATIENTS WITH SYSTEMIC SCLEROSIS
K.A. Simic Pasalic1, N. Pilipovic1, N. Damjanov2, N. Gavrilov1, J. Petric3 1Clinical rhumatology V; 2Head of Institute of rheumatology, Institute of rheumatology; 3Internal medicine department, Railway Health care Institute, Belgrade, Serbia
Background: Systemic sclerosis (SSc) is a multisystem disorder with a complex pathogenesis which is largely unclear. Data about the extent and mechanism of bone loss in SSc patients are inconsistent, so far.
Objectives: To analyse bone mineral density (BMD) parameters in female patients with SSc.
Methods: Fifty SSc patients (ACR SSc criteria fulfilled), all postmenopausal, with no other risk factors for Osteoporosis (OP), were evaluated for their BMD, T-score on lumbar spine and femoral neck by dual x ray absorptiometry (DXA) using Lunar Prodigy device. The results were compared to the same parameters obtained in control group of healthy women comparable according to age, menopause duration, body mass index (BMI). We assessed the influence of age, menopause duration, BMI, clinical SSc subtype (limited/diffuse), disease duration, activity and previous treatment to BMD, T-score. Student's t test, Pearson and Spearman's test were used, as appropriate
Results: All patients were female, mean age: 57,22±8,69 years, mean menopause duration: 10,00±6,85 years, mean disease duration: 9,06±6,8 years, mean BMI: 24,42±4,3 kg/m2. Limited SSc subtype had 31 (62%) and active disease 30 (60%) patients. Normal bone density was found in 21 (42%) SSc patients vs 14 (28%) controls, osteopenia was recorded in 20 (40%) SSc vs 23 (46%) controls, while osteoporosis in 9 (18%) SSc patients vs 13 (26%) women in control group. No significant difference between BMD(p=.312) and T-score(p=.543) on lumbar spine, nor BMD(p=.314) and T-score(p=.426) on femoral neck were found between SSc patients and controls. In SSc patients, no correlation was found between BMD parameters and SSc clinical variables, previous treatment, or demographic characteristics, while in the control group negative correlation was found between both lumbar spine BMD (p=.002), T-score (p=.002) and femoral neck BMD (p<.001), T-score (p=.002) and age and menopause duration, as well as positive with BMI (p=.004).
Conclusion: Differences in SSc duration, activity, clinical subtype and treatment had no impact on bone mass. OP was recorded less frequently, than in healthy controls. Statistically significant correlation between BMD, age, menopause and BMI was recorded in control group, but was not present among female SSc patients.
Disclosure of Interest: None declared
Ann Rheum Dis 2009;68(Suppl3):465
Scleroderma, myositis and related syndromes
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