[2008] [SAT0185] THYROID AUTOIMMUNE DISEASES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
D.P.P.O. Viggiano1, A.O.S. Montandon2, V.S. Barbosa2, N.A. Silva2 1Department of Endocrinology and Metabolism; 2Department of Rheumatology, Federal University of Goiás, School of Medicine, Goiânia, Brazil
Background: Thyroid autoimmune diseases have been associated with a variety of rheumatologic diseases, including Systemic Lupus Erythematosus (SLE). The association of SLE and thyroid autoimmune diseases is not well clear.The prevalence of autoimmune thyroid diseases (3.9 - 24%) and antithyroid antibodies (11-51%) in SLE varies considerably. Early reports were based on short terms studies of small cohort.
Objectives: To estimate the prevalence of thyroid autoimmune diseases in patients with SLE,the positivity of thyroid antibodies and abnormalities in thyroid function, to evaluate the association between thyroid dysfunctions and the SLE disease activity status, immunosuppressive agents use and the duration of disease.
Methods: Transversal study to compare the prevalence of thyroid disorders in 106 patients with SLE and an age and sex matched control group of 102 patients without SLE. The patients were submitted to clinical and laboratorial evaluation; the tests included antiperoxidase and antithyroglobulin antibodies, TSH, free T4 and T3.
Results: We detected higher prevalence of sub clinical hypothyroidism (11%) and clinical hypothyroidism (13%) in the group of patients with SLE when they were compared to the control group, 7% and 1%, respectively (p < 0,001). The hyperthyroidism occurred in a same frequency in the two groups (3%;2%). The positivity of antithyroid antibodies was higher in the group with SLE (23% x 19%, p = 0,025). The relative risk of the patients with SLE to develop thyroid dysfunctions was 1,6. It does not appear to be association between thyroid abnormalities and the SLE disease activity status, the use of immunosuppressive agents and the duration of the SLE.
Prevalence of thyroid dysfunctions | SLE | Control group | p |
|---|
| N (%) | N (%) | |
|---|
| Antithyroid antibodies | 24 (23) | 19 (19) | 0,025** | | Sub clinical hypothyroidism | 12 (11) | 6 (6) | <0,001** | | Clinical hypothyroidism | 14 (13) | 1 (1) | <0,001** | | Hyperthyroidism | 3 (3) | 2 (2) | 1,000 |
Conclusion: The result of this study confirm the hypothesis that the hypothyroidism and the positivity of antithyroid antibodies were more prevalent in patients with SLE than in general population, and they were independent of the activity and duration of the disease and immunosuppressive agents use.
References: Merrill JT, Byon JP. Hormones and Gender Related Issues. In: WALLACE, D. J.; HAHN, B.H. (Ed). Dubois' Lupus Erythematosus. 7 ed. Philadelphia: Lipippincott Willians & Wikins, 2007. Cap 64.
Pyne D, Isenberg DA. Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheum Dis 2002;61:70-72.
Ann Rheum Dis 2008;67(Suppl II):492
SLE, Sjögren's and APS Clinical aspects and treatment
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