[MON-34] Longitudinal Changes in Testosterone over 5 Years in Community-Dwelling Men

Andre B Araujo, Zumin Shi, Sean A Martin, Gary A Wittert. New England Research Institutes, Inc, Watertown, MA; University of Adelaide, Adelaide, Australia.

There are few population-based studies reporting longitudinal changes in testosterone (T) levels, and limited information on risk factors for longitudinal change in T. We examined changes in serum T levels assessed by liquid chromatography mass spectrometry (LC-MS/MS) among a cohort of 1,588 men aged 35-80y at baseline with available data at 2 clinic visits separated by 5 years. Excluded from analyses were men on medications (N=102) or with medical conditions (N=45) known to affect hormones, and men with pathological laboratory values (N=59), leaving 1,382 for analysis. Multivariate linear regression was used to assess the association between baseline predictors as well as change in predictors and annualized change in T. All models were minimally adjusted for baseline age. At baseline, mean age was 54±11y, 21% were unmarried, 19% were current smokers, 30% had BMI≥30kg/m2, 48% had waist≥100cm, and 8% were depressed. Mean baseline T was 16.2±1.4nmol/L, with 3%<8nmol/L, 36% 8-15nmol/L, and 61%>15nmol/L. Mean T at follow-up was 15.6±1.4nmol/L, representing a non-significant T change of -0.13nmol/L/y (95% CI: -0.62, 0.41) or an approximate decline of -0.80%/y. Baseline variables significantly associated with annualized T changes were: being unmarried (-0.18nmol/L/y vs. married, p<.01), central obesity (+0.13nmol/L/y vs. non-central obesity, p<.01), BMI≥30kg/m2 (+0.22nmol/L vs. <25kg/m2, p<.01), and current smoking (-0.17nmol/L/y vs. non-smoker, p<.01). The effects of smoking status was driven by decreasing T in men who quit smoking (-0.17nmol/L/y vs. non-smoker at both time points, p<.01). The effects of central obesity and high BMI were driven by changes in status between baseline and follow-up, with for instance, a T change of -0.25nmol/L/y in men who became centrally obese (waist≥100cm) and a T change of +0.20nmol/L/y in men who became non-centrally obese, both compared to men who were not centrally obese at both time points (both p<.01). In addition, men who were depressed at both time points had a significantly greater T decline (-0.28nmol/L/y vs. men without depression at both time points, p<.01). In conclusion, this study strongly suggests that (i) T decline is not an inevitable part of aging and (ii) variability in T changes are largely explained by smoking behavior and intercurrent changes in health status, particularly obesity and depression.

Sources of Research Support: This study was supported by the National Health and Medical Research Council of Australia (NHMRC grant 627227).

Nothing to Disclose: ABA, ZS, SAM, GAW

Date: Monday, June 25, 2012
Session Info: POSTER SESSION: Male Reproductive Endocrinology (1:30 PM-3:30 PM)
Presentation Time: 1:30 pm
Room: Expo

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