[O-102] ASSOCIATION OF SHORT-TERM AND LONG-TERM PHYSICAL ACTIVITY ON IMPLANTATION IN IN VITRO FERTILIZATION (IVF) CYCLES.
K. C. Calhoun, A. Z. Steiner, M. Wen, A. Calingo, K. Evenson. Obstetrics and Gynecology, UNC-Chapel Hill, Chapel Hill, NC; Epidemiology, UNC Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC.
OBJECTIVE: To estimate the association between short-term and long-term physical activity on implantation following IVF.
DESIGN: Prospective, cohort study.
MATERIALS AND METHODS: Women (N=100) beginning non-donor IVF cycles (fresh or frozen) completed the previously-validated Kaiser Physical Activity Survey (KPAS), which quantified activity over the past year in four domains: household and family care, occupation, active living habits, and sports (scored 1-5, least to most active). Participants wore an ActiGraph acclerometer from day of embryo transfer until the day of βHCG level, which precisely documented the the duration, intensity and frequency of physical activity, as well as sedentary behavior. KPAS scores and acclerometry counts (activity/minute) were compared between women who conceived (βHCG>5 IU/L) and women who did not conceive using non-parametric tests and unadjusted logistic regression.
RESULTS: Of the 87 women who provided sufficient data for analysis, 44 (50.6%) conceived. Women who conceived had higher median KPAS scores for active living (3.0, interquartile range (IQR): 2.3-3.3) and sports (3.8, IQR: 2.8-4.0) than women who did not conceive (2.5, IQR: 2.3-3.0 and 2.8, IQR: 1.8-4.0,) (p 0.04 and 0.05, respectively). There were no differences for household and occupational scores by IVF outcome. The odds of conceiving was 2.93 (95% confidence interval (CI): 1.21-7.10) higher for women with active living scores above the median than women with scores below the median. Following embryo transfer, women were sedentary a median of 9.9 waking hours/day (IQR: 8.9-11.1) and participated in moderate/vigorous activity for a median of 15.3 minutes/day (IQR: 7.3-24.4). Time spent sedentary or in moderate/vigorous activity following embryo transfer did not differ by IVF outcome.
CONCLUSION: Physical activity following embryo transfer does not appear to differ between those that will or will not conceive; however, women, who are more active in the year preceding IVF are significantly more likely to conceive.
Supported by: NIH UL1RR025747.
Monday, October 22, 2012 4:30 PM
Oral Session: Environment and Reproduction