[P-485] OUTCOMES OF MEDICALLY-INDICATED (MED) OOCYTE CRYOPRESERVATION (OC) CYCLES PERFORMED FOR FERTILITY PRESERVATION (FP) COMPARE FAVORABLY TO OC CYCLES OF INFERTILE WOMEN WHO HAVE COMPLETED A THAW CYCLE.

N. Noyes, J. Knopman, P. Labella, M. Werner, C. McCaffrey, J. A. Grifo NYU Fertility Center, Dept. OB/GYN, NYU School of Medicine, New York, NY; Dept. OB/GYN, NYU School of Medicine, New York, NY

OBJECTIVE: As more reproductive-age women are diagnosed with and survive cancer, OC use is increasing as a means of FP, particularly in those without a male partner. We compared outcomes of medically-indicated (MED) OC cycles to those of infertile women completing an OC thaw cycle (THAW), including their meiotic spindle evaluation (MSE). All MII oocytes cryopreserved in our lab undergo MSE 2 h post-harvest.
DESIGN: Retrospective
MATERIALS AND METHODS: 31 MED (520 retrieved eggs) and 28 THAW (512 retrieved eggs) OC cycles were reviewed. Tumors in the MED group included 13 GYN, 10 breast, 3 leukemia, 2 colon, 2 CNS and 1 sarcoma. All patients underwent standard ovarian hyperstimulation followed by retrieval, MSE 2 h post-harvest, then OC of all MII oocytes. Both slow freezing and vitrification were used. 4 MED pts froze ½ as zygotes.
RESULTS: In the THAW cycles, there were 16 (57%) pregnancies: 12 women delivered 17 liveborns (5 twins), 3 have ongoing gestations and 1 miscarried. 90% of eggs survived and there was a 94% pre-cryo to post-THAW MSE correlation. 2 MED thaw cycles resulted in 1 pregnancy. Cycle comparisons for THAW vs. MED are shown in the Table.

Table. Comparison of medically-indicated (MED) OC cycles and OC cycles of infertile women who completed a thaw (THAW).

	THAW	MED	P
Mean age at retrieval (y)	31±1(range 21-38)	31±1 (range 20-40)	.9
Mean E2 day hCG (pg/ml)	3086±300	1788±176	<.001
Mean no. eggs retrieved	18±2 (range 6-61)	17±2 (range 5-38)	.8
Mean no. MII for OC	14±2	11±1	.1
Mean no. MII with pre-cryo spindle	10±1	9±1	.08

CONCLUSIONS: The majority of oocytes in both groups were mature (MII) and exhibited a spindle. Women diagnosed with cancer can achieve adequate ovarian stimulation, egg production and MSE despite limited time to complete OC treatment and multiple outside stressors, including their underlying disease and its management. Based on our preliminary THAW data, we believe cancer pts should have a reasonable chance for pregnancy using their frozen eggs.
Supported by: FSH

Wednesday, October 21, 2009 7:00 AM

Poster Session II: Fertilization