[P04.023] Cognition and Waking Electroencephalogramm in REM Sleep Behavior Disorder Patients.

Jessica Massicotte-Marquez, Anne Decary, Melanie Vendette, Annie Mathieu, Dominique Petit, Sylvie Rompre, Julie Carrier, Jacques Y. Montplaisir, Montreal, QC, Canada

OBJECTIVE: The aim of the present study was to verify the functional significance of the EEG slowing in RBD patients in relation to their cognitive performance. BACKGROUND: A recent study performed in our laboratory showed a slowing of waking EEG in RBD patients compared to healthy subjects (Fantini et al., 2003), suggesting that RBD could be a prodrome of a neurodegenerative disease. DESIGN/METHODS: Fourteen men (mean age: 66.64 2.05y; mean educational level: 12.21 1.08y) meeting the ASDA criteria for idiopathic RBD and fourteen healthy men matched for age and education (mean age: 65.73 2.24y; mean educational level: 13.54 1.05y) underwent one night of polysomnographic recording, a 10-minute waking EEG recording and a full neuropsychological assessment. Quantitative EEG analyses were performed for frontal, central, parietal, occipital and temporal regions during wakefulness. RESULTS: Compared to controls, RBD patients had more Delta power (p<0,005) and more Theta power (p<0.02) in all cortical regions. These patients showed significantly poorer performance in Semantic Verbal Fluency (p<0.01), Similarity task (p<0.02), Digit Coding task (p<0.05) and Trail Making task (p<0.0007). Moreover, we found memory impairments in Word Memory Learning task (Rey Auditory Verbal Learning Test) (p<0.05), in immediate recall (p<0.03), and for the True (p<0.01) and False (p<0.04) recognition conditions. However, correlations between quantitative EEG and cognitive abnormalities were not statistically significant. CONCLUSIONS/RELEVANCE: The present results show that both waking EEG and cognitive performance of male RBD patients are altered independently compared to controls. However we did not find visuospatial constructional or visuospatial learning dysfunction as reported previously in this patient population (Ferini-Strambi et al., 2004). Taken together, these results are congruent with the hypothesis that RBD is an early manifestation of a neurodegenerative disease. Supported by: Canadian Institutes of Health Research and Fonds de Recherche en Sant du Qubec.
Category - Sleep Disorders
SubCategory - Parasomnias

Wednesday, May 2, 2007 7:00 AM

Poster Sessions: Sleep Disorders (7:00 AM-10:00 AM)

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