[S43.006] Efficacy of Transcranial Direct Current Stimulation on Working Memory and Mood in Patients with Temporal Lobe Epilepsy

Anli Liu,1Orrin Devinsky,1Andrew Bryant,1Ashlie Jefferson,1Daniel Friedman,1Mouhsin Shafi,2William Barr,3Daniel Press,4Susan Herman,5Margaret O'Connor,5Steven Schachter,5Alvaro Pascual-Leone5
1New York, NY, USA, 2Cambridge, MA, USA, 3New York City, NY, USA, 4Winchester, MA, USA, 5Boston, MA, USA

OBJECTIVE: Our aim is to evaluate whether serial sessions of transcranial direct current stimulation can induce improvements in working memory function, depressive symptoms, and quality of life in patients with well-controlled temporal lobe epilepsy.
BACKGROUND: Memory dysfunction and depression are frequently comorbid with temporal lobe epilepsy. Transcranial direct current stimulation (tDCS) is a safe, non-invasive method of brain neuromodulation. Previous pilot studies employing tDCS have demonstrated a benefit for working memory and depressed mood in both healthy and neurologically impaired subjects.
DESIGN/METHODS:This is a randomized, double-blinded, sham-controlled pilot study with 24 adult patients (ages 18-62) with well-controlled temporal lobe epilepsy. Anode was placed over the left dorsolateral prefrontal cortex and cathode over the right supraorbital region. Subjects randomized to the active tDCS arm received 5 sessions of 2 mA of direct current for 20 minutes. We performed several measures of verbal and visuospatial working memory, mood (Beck Depression Inventory [BDI], Neurological Disorders Depression Inventory for Epilepsy [NDDI-E]), quality of life (Quality of Life in Epilepsy [QOLIE-31]), and seizure frequency immediately before and after stimulation, and after 2 and 4 weeks.
RESULTS: Subjects randomized to the treatment arm were similar in educational background, verbal IQ scores, seizure frequency, and baseline working memory and mood scores compared to control subjects. We found that active but not sham tDCS significantly improved mood scores measured by the BDI and NDDI-E, but did not improve working memory performance. There was a trend toward benefit in quality of life (QOLIE-31). There was no increase in the frequency of seizures during or after active stimulation.
CONCLUSIONS: Active but not sham tDCS significantly improved mood symptoms and did not increase seizure frequency in patients with well-controlled temporal lobe epilepsy.
Study Supported by: Epilepsy Foundation, American Epilepsy Society, American Brain Foundation
Category - Epilepsy and Clinical Neurophysiology (EEG): Co-Morbidities

Wednesday, April 30, 2014 4:50 PM

S43: Platform Blitz: Epilepsy and Clinical Neurophysiology (4:00 PM-5:45 PM)


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